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Recommended Books on Pharmacogenomics
Applying Genomic and Proteomic Microarray Technology in Drug Discovery Microarrays play an increasingly significant role in drug discovery. Written by a leader in the field, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and evaluates current scientific research using microarray technology in genomic and proteomic applications. The author addresses the drawbacks, helping you avoid unnecessary pitfalls, and provides practical tips on how to employ the technology in drug discovery and development. The book details the commercial landscape, covering the many issues surrounding the future adoption of gene expression and protein microarrays for pharmacogenomic and pharmacoproteomic applications. The author critically assesses those studies that have helped define applications in genomics and proteomics, explains gene expression microarray applications, and examines the utility of the protein microarray. He covers alternative substrates and the preparation of various surface chemistries together with their suitability for immobilization of nucleic acids and proteins. He delineates the mechanics of microarraying including environmental conditions, printer and pin performance, as well as discussion regarding setting up the print run. The book supplies protocols for printing nucleic acids and proteins and an in-depth discussion of other important parameters such as print buffers (inks) and factors influencing print quality. An understanding of the making of a microarray is fundamentally important to those interested in producing "spotted" arrays and their proper use. As this technology expands in popularity and usefulness, industry experts must grasp the fundamental principles behind it, its strengths, and its limitations. A basic reference for users of microarray technology in drug discovery, this book offers a detailed perspective and insight into the present and future uses of this technology.
Molecular Analysis and Genome Discovery This advanced level textbook provides a comprehensive overview of recent developments in the area of molecular based diagnostics (including nucleic acids, biosensors and immunoessays) of disease markers. It also covers the impact of techniques such as in vitro nucleic acid amplifications (e.g. PCR) and other amplification methods, as well as gene and biochip production and automated techniques such as fluorescent sequencing.
The book discusses key concepts where new and merging areas, including pharmacogenomics, proteomics and functional genomics, are being researched and developed. In addition, examples are given where this new area of bioscience has or may be successfully applied.
This advanced level textbook provides a comprehensive overview of recent developments in the area of molecular based diagnostics (including nucleic acids, biosensors and immunoessays) of disease markers. It also covers the impact of techniques such as in vitro nucleic acid amplifications (e.g. PCR) and other amplification methods, as well as gene and biochip production and automated techniques such as fluorescent sequencing. The book discusses key concepts where new and merging areas, including pharmacogenomics, proteomics and functional genomics, are being researched and developed. In addition, examples are given where this new area of bioscience has or may be successfully applied.
Genetic Variance Detection : Technologies for Pharmacogenomics (Nuts & Bolts series) (Nuts & Bolts series) This comprehensive reference for novice students and experienced scientists studying DNA in organisms compares and evaluates the technological choices available in detecting genetic variances in pharmacogenomics. Commonly used technologies such as sequencing, DNA array and chip technologies, mass spectrometry, gel- and chromatography-based technologies, as well as less commonly used methods are described in detail and illustrated with specific examples. Expert advice is presented on technological options to facilitate decisions about the utility and applicability of individual technologies for specific needs.
Pharmacogenomics in Drug Discovery and Development (Methods in Molecular Biology)
Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In Pharmacogenomics in Drug Discovery and Development, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. Divided into three sections, the volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases. Comprehensive and up-to-date, Pharmacogenomics in Drug Discovery and Development is an ideal volume for scientists striving to transform disease treatment into disease prevention.
Microbial Genomics and Drug Discovery Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. The book discusses potential pathways for effective infection control, inhibition of antibacterial resistance, and acceleration of the drug discovery process. This comprehensive reference describes procedures to recognize common targets in various bacterial species for the design of broad-spectrum antibiotics and clearly illustrates the use of pathway tools in a genomics-based drug discovery project.
Pharmacogenomics and Proteomics: Enabling the Practice of Personalized Medicine The new "molecular economy," fundamentally driven by understanding molecules and their interactions, has spawned an exciting discipline referred to as "clinical" pharmacogenomics or pharmacogenetics. Combining this discipline with our knowledge of protein function and regulation (proteomics), a more complete understanding of systems physiology is achieved-giving rise to a "systems biology" perspective. From this new perspective, the practice of medicine is becoming more dependent on the application of biomarkers-genomics, proteomics, and other functional biomarkers-toward personalized medicine, thus allowing a practical convergence to optimize matching of the right patient and the right diagnosis with the right drug and the right dose at the right time. To enable the practice of personalized medicine with an understanding of pharmacogenomics and proteomics, this book reviews:
- the fundamentals of molecular biology and general clinical implications important in understanding fundamental concepts, a general review of ethical considerations, methods of predicting response using artificial networks, regulatory issues, reimbursement, quality assurance considerations, and future market analysis;
- methodologies that merge the disciplines of pharmacogenetics with those of proteomics, metabolomics, and metabonomics;
- specific clinical applications of pharmacogenetics of major drug groups, specialties, and diseases, and how they are linked to potential clinical management; and
- selected biotechnologies relevant to the application of clinical pharmacogenomics and proteomics to clinical practice.
As the new molecular economy emerges, this text provides the basic pharmacogenomic and proteomic tools needed to understand this new, rapidly evolving, and exciting discipline.
Referenced Review Questions in Pharmacogenomics The application of pharmacogenomic principles to medication use is beginning to radically change the way drugs are selected and monitored. Those who wish to evaluate their knowledge in the basics of the subject and in applications such as drug selection and drug avoidance will therefore find Referenced Review Questions in Pharmacogenomics an invaluable guide to this rapidly evolving field. The book features three sections:
- Questions
- Answers and Explanation
- References (provided as a basis for the answers and to encourage the reader to review the references and expand his/her knowledge or area of expertise)
The Questions section is further subdivided into the following topics: The Basics; Cytochrome P450s and Other Enzymes; Receptors; N-Acetyl Transferases; Asthma and Other Pulmonary Diseases; Neurology; Antimicrobials and Infectious Disease; Immunology; Oncology; Analgesics, Sedatives, Hypnotics, and Anesthetics; Psychiatry; Antiinflammatory Drugs; Oral Hypoglycemics; Glucose-6-phosphate Dehydrogenase; Anticoagulants; Inflammatory Bowel Disease and Other Gastrointestinal Drugs; Bone and Mineral Metabolism; and Cardiovascular Drugs. A large portion of the specific information on individual drugs is derived from the pharmaceutical industry, which performs the majority of the pharmacogenomics testing as part of pre-market approval.
Because the emerging concept of personalized medicine is placing significant demands on physicians and on pharmacists in particular, they-as well as academic and practicing clinical chemists and pathologists who have an interest in pharmacogenomics-will find Referenced Review Questions in Pharmacogenomics especially useful. Technologists and other healthcare professionals who have an interest in molecular medicine and who would like to broaden their professional horizons will also find this text enlightening.
Pharmacogenomics, Second Edition (Drugs and the Pharmaceutical Sciences) Reflecting the shift from genetics to genomics in the pharmaceutical sphere, this Second Edition traces the evolution of the science of pharmacogenetics and gathers research from the forefront of the field-spanning the most influential breakthroughs in molecular diagnostics, metabonomics, proteomics, bioinformatics, disease mapping, pharmacodynamics, and disease gene identification.
Pharmacogenomics: The Search for Individualized Therapies This work represents the first comprehensive publication in the innovative field of pharmacogenomics, a field which is set to revolutionize pharmaceutical research. In addition to renowned editors, the list of contributors is a "who-is-who" in the field. Broad coverage of all aspects of pharmacogenomics with a full presentation of applications to disease conditions is featured. Anyone involved in pharmaceutical research and drug development needs this book to keep up with this new and revolutionary approach
Pharmacogenomics: Methods and Protocols (Methods in Molecular Biology) (Methods in Molecular Biology) Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.
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