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Toxicogenomics in risk assessment: applications and needs.

Boverhof DR, Zacharewski TR

Department of Biochemistry and Molecular Biology, National Food Safety and Center for Integrative Toxicology, Michigan State University, East Lansing Michigan 48824, USA.

Since its inception, there have been high expectations for the science of toxicogenomics to decrease the uncertainties associated with the risk assessment process by providing valuable insights into toxic mechanisms of action. However, the application of these data into risk assessment practices is still in the early stages of development, and proof of principle experiments have yet to emerge. The following discusses some potential applications as well as impediments that warrant a concerted investigation from all stakeholders in order to facilitate the acceptance and subsequent incorporation of toxicogenomics into regulatory decision making.

Published 12 January 2006 in Toxicol Sci, 89(2): 352-60.
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